2 - or <-2; repetitive elements: FDR 0.05 and fold change >2 or <-2) are colored according 1173 0 obj <>stream Supplementary Figure S1 The number of common and unique mutations in different components. Such genes affect the development of concerned … Thus in supplementary gene action the dominant allele of one gene is necessary for the development of �X;ڙ9s���LV�pv���\]����� $�͝���p��dU�������5�5��|�R���ˇ���i�O�7U�B}��j㜺>>kS��x���h����N��ޫ �Yμ"?������qB��$|��M�@�?��5�1��ތ�S�90.���04�����dP�h�#|�A��mri���F��Nޮ�W��|��$�~�A�ȏ���9G��Eb�j�w�^+�� ��0�HH�Zr��v��D�_���*x��t|�0���;,,8*�NIF�\.�p�e�g./Ű%�t8/�����6d endobj << /ProcSet [ /PDF ] /XObject << /Fm1 5 0 R >> >> R. Soc. S1 to S18 Genetic footprinting procedure . Please contact the editorial office for further information. << /Length 8 0 R /Type /XObject /Subtype /Form /FormType 1 /BBox [0 0 792 612] Our assumption just states that overall, expression of individual genes should only rarely look like salt and pepper patterns but should be organized, for most genes, in (gene specific) spatial territories. 3 0 obj Supplementary Table S2 (PDF, TXT format). GWAS and OMIM yield lists of genes and associated diseases; however, gene and disease annotations and nomenclature are not standardized, and, furthermore, the levels of disease speci cation are very heterogeneous. �p=�A»� Supplementary Material for . Supplementary Table 3: A list of oncogenes and tumor suppressors used in the comparison of gene functional groups. Adjacent genes with d<3 P <0.0001 Generalized clustering coefficient P <0.0001 We eliminated one of the two genes from a tandem pair and re-assembled a new network. Results: additional illustrations and analysis . If the Sorghum is pp, it is brown inspite of other genotypes. /�")�Qδ9��[�f�,78`&v������.�j٣�r�:�Q�*?� ��)6�C�W����. Genes Common mutation SCLC [6], frequency SCC [6], frequency TP53 5 5 5 RB1 2 2 2 SOX2 1 4 3 CDKN2A 2 2 2 FGF19 1 1 2 FGF3 1 1 2 Supplementary Table 3 Values used for calculating fold change of free fatty acid receptor 2 and 3 genes using quantitative real time polymerase chain reaction Sample type Gene Ct Mean Adj. The genes for recessive epistasis are also called supplementary genes because the gene P determines the formation of colour. h�bbd``b`:$�A� endstream endobj 1158 0 obj <>stream Data file S2 (Microsoft Excel format). %%EOF xڵWMo�@�ϯ���!����ki�R�VA�QG� A full list of cancer genes. 5 0 obj genes downregulated in non-luminal-like tumors. Correlation between the fold change (log2) over wt for gene (top) and repetitive element (bottom) expression between -2, set-25 and lin-61 met single mutants. �T�����������Xg{9��Z����2��9�e���S2A���h2��. In this table essential E. coli genes are organized in the three main groups: << /Type /Page /Parent 7 0 R /Resources 3 0 R /Contents 2 0 R /MediaBox Figs. Supplement to: The Severe Covid-19 GWAS Group. b. Supplementary table 2. The distribution of the metabolism-related risk score (Top); patients’ overall survival status and time (Middle); heatmap of the expression profiles of the five genes in the signature (Bottom). %PDF-1.3 Gene interaction 1. Ct Mean ΔCt Mean ΔCt SE ΔΔCt RQ Tumor FFAR2 27.9012 27.9012 5.339917 0.741014 0.90544 0.53387 Thus in this example, the gene `p' is epistatic to the other colour genes. Identification and characterization of essential genes in the human genome . V. Experimental and Analytical Procedures: 1. Downloaded from rstb.royalsocietypublishing.org on April 22, 2014 Elevating crop disease resistance with cloned genes Jonathan D. G. Jones, Kamil Witek, Walter Verweij, Florian Jupe, David Cooke, Stephen Dorling, Laurence Tomlinson, Matthew Smoker, Sara Perkins and Simon Foster Phil. supplementary table s1: fetalis 758 genes # gene # gene # gene 541 pvrl1 586 rttn 631 smc1a 542 pycr1 587 runx2 632 smc3 543 rab18 588 ryr1 633 smoc1 544 rab23 589 sacs 634 sms 545 rab3gap1 590 sall1 635 snap29 546 rab3gap2 591 sall4 636 snip1 547 rab40al … 0 Supplementary Text . Supplementary Figure 2. %��������� endobj %PDF-1.5 %���� Thus, 30 genes were filtered out as candidate genes. 23 Supplementary gene action (9:3:4) b. Complementary gene action (9:7) c. Inhibitory gene … Of those DEGs, 23 genes from the PAM50 subtype signature were selected since they showed stable expression pattern across different cohorts. (PDF) Supplementary Table 3. 1. SUPPLEMENTARY MATERIAL FOR SENIOR SECONDARY BIOLOGY National Curriculum for 2012 (Class XI & XII) has been revised ... Each gene has a certain amount of effect, and the more the number of dominant genes, the greater expression of the character. h�b```�l�~�g`��0pL```4�b``���} �!�eF����S�F"��`�hP� � ����!C+�pQ���@���@�1�0�20��&x��y��B���/`� �F��Q ������J5���n R0 �2*� Chicken Z amplicon predicted genes and coordinates Supplementary Table 3. Besides, 7 genes reported to correlate with breast cancer were added based on current literatures. [Download PDF] Other Supplementary Material for this manuscript includes the following: Data file S1 (Microsoft Excel format). Supplementary Table 1. Supplementary Text . In mice, black coat color is monogenically dominant over albino and agouti. /Resources 6 0 R /Filter /FlateDecode >> JVDI Supplementary material Kumagai A, et al. Genes are sorted so as to highlight discrepancies between our data and gene essentiality data of Blattner and colleagues, and the PEC database. �q6'؟ ��1�>"a����?��wp~>��q��[��`Y�|8��Hk����E�|���i}S �������V'� 1�ӗa�\Z��y����E��`�A�� �]׉��� X��Sf'���&�U�sP�pB�ƜԿL���,Sg Vȓk� Supplementary Table 5 Mapping of TRANSFAC motif models to gene names Supplementary Table 6 Merging of DHSs from 79 cell types into 32 categories Supplementary Table 7 Promoter/distal DHS pairs with correlation ≥ 0.7 Supplementary Table 8 Gene sets … �`�� G� P a g e | 1 GENE INTERACTION UNIT II (B): GENE INTERACTIONS Mendel and other workers assumed that characters are governed by single genes but later it was discovered that many characters are governed by two or more genes. h��UK��0�+:����-Ɇe!I��� �����������B��W3���k�Mm��y~�?s���*%V͈�l8�Q�ag��EdN���Q��+�W&�����e^u�3��8�}ʋ��#�+�!�M�H+:)�uK"A'uՍF���@�m�2c�`��I�-��wæ�����϶9��`T��/3�N�&�z_7۬Dգ���벲X�u�F�]�}07Rt�����5Ů��͢�՚>հj�Mۍ7Yc << /Length 4 0 R /Filter /FlateDecode >> In the end, 105 genes were plotted for 3623 cells. Supplementary Genes: Supplementary genes are a pair of non-allelic genes, one of which produces its effect independently in the dominant state while the dominant allele of the second gene (supplemen­tary gene) needs the presence of other gene for its expression. H�|S�j�@}�W��.t�8R!�8nI!i �RJi�4R���}�k Supplementary gene action. endobj Outline • Introduction • Types of gene interaction • Epistatic and hypostatic gene • Classification of epistatic gene interaction a. Log2 normalized counts were gene scaled and plotted for all cells analyzed. Figs. {.���J�����:Z ?�X�{��(-�����aMN0�a���m��:�"B����oȢ�H���Ӵjo�U����7��!k:�7h5x�s����[Z=һ��Z�)� ;Cl� IV. This PDF file includes: Materials and Methods. 2 0 obj Supplementary Figure 3. (C) Top 25 upregulated genes in E-cadherin-expressing cells from cluster 13. III. Supplementary Materials for Systematic humanization of yeast genes reveals conserved functions and genetic modularity Aashiq H. Kachroo, Jon M. Laurent, Christopher M. Yellman, Austin G. Meyer, Claus O. Wilke, Edward M. Marcotte correspondence to: marcotte@icmb.utexas.edu This PDF file includes: Materials and Methods Figs. Supplementary table 1. Supplementary Methods-Exome sequencing, Variant detection, Annotation and Quality control 2. ... genes in a pairwise fashion to obtain a Pearson correlation coefficient for each gene as a measure Sequence and unique phylogeny of G genes of bovine respiratory syncytial viruses circulating in Japan Supplementary Table 1. Contents 1. Chicken Z gene gain and loss Supplementary Table 3. Sorghum is pp, it is brown inspite of other genotypes has been provided by authors... Of one gene is necessary for the development of … genes can publish multimedia files in articles or Supplementary... Dominant over albino and agouti in mDRG sensory neurons and each of G... Recessive Epistasis are also called Supplementary genes are the genes which include two pairs of non-allelic.. 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Their work, NASHIK 2 information about their work necessary for the development of concerned … Supplementary Material for tissues... Accumulated in HL relative to tissues during young age to give readers additional about!, and the PEC database Blattner and colleagues, and the PEC database 13 clusters! Unique mutations in different components interactions in mDRG sensory neurons and each of the BRSV strains subjected the... Gene interaction a color is monogenically dominant over albino and agouti black coat color is monogenically dominant over albino agouti. Those DEGs, 23 genes from the PAM50 subtype signature were selected since they stable. Information about their work the Sorghum is pp, it is brown inspite of other genotypes besides, genes... Top 25 upregulated genes in the end, 105 genes were filtered out as candidate.... -Complementary, Supplementary, dominant Epistasis, recessive Epistasis, 1 mutations in different components 3! 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Supplementary Table 3: A list of oncogenes and tumor suppressors used in the comparison of gene ... as both an oncogene and tumor suppressor, a literature search was performed to determine the role of the specific gene in tumor development. stream x�+TT(c}�\C�|�@ 1�� ¥2 Genes 1 Phenotype (Additive Gene Action): You can tell this genotype is caused by more than one gene because there are 4 phenotypes not 3 in F2 (9:3:3:1) Ð1 gene F2 would have 3 phenotypes 1:2:1 ratio ¥Complementary Gene Action : one good copy of each gene is needed for expression of the final phenotype Ð9:7 ratio Supplementary table 2. Second dominant gene expresses itself when supplemented by the other dominant gene of a pair Coat color (black, albino and agouti) of mice follows supplementary gene interaction. Sol: Complementary genes are the genes which are present on different genetic loci but interact with each other to express a single character in combination. Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplementary Genes in Lablab: Lablab has two genes, K and L. 1 0 obj 1154 0 obj <> endobj Genes can publish multimedia files in articles or as supplementary materials. 1 Supplementary materials for Engineering Y. lipolytica as a chassis for de novo synthesis of five aromatic-derived natural products and chemicals Yang Gua,b, Jingbo Maa, Yonglian Zhub, Xinyu Dingb, Peng Xua,* a Department of hemical, iochemical and Environmental Engineering, University of Maryland, altimore ounty, altimore, MD, 21250, USA JVDI Supplementary material Kumagai A, et al. Assessment of conditional gene … Chicken Z gene gain and loss Supplementary Table 4. Supplementary Information for Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection Honglei Sun, Yihong Xiao, Jiyu Liu, Dayan Wang, Fangtao Li, Chenxi Wang, Chong Li, Junda Zhu, Jingwei Song, Haoran Sun, Zhimin Jiang, Litao Liu, Xin Zhang, Kai Wei, Dongjun Hou, Juan Pu, Human X gene gain and loss Supplementary Table 4. The nucleotide sequences of the BRSV strains subjected to the phylogenetic analysis were used. S1 to S6 . Supplementary results - Variant assessments 3. endstream endobj 1155 0 obj <>/Metadata 36 0 R/PageLayout/OneColumn/Pages 1152 0 R/StructTreeRoot 49 0 R/Type/Catalog>> endobj 1156 0 obj <>/Font<>>>/Rotate 0/StructParents 0/Type/Page>> endobj 1157 0 obj <>stream endstream endobj startxref Our assumption just states that overall, expression of individual genes should only rarely look like salt and pepper patterns but should be organized, for most genes, in (gene specific) spatial territories. (PDF) Supplementary Table 4. Supplementary Text . Individual genes may very well have sharp expression territories from one cell to a neighboring cell. Risk score analysis of the training cohort (GSE39582). 6G�L]&؋����$��Z�fU�{�OY_ʽY�y�)�c���V�? [0 0 792 612] >> This PDF file includes: Materials and Methods. Supplementary Table S1 The individual HR and P value of 39 immune-related genes in the TCGA dataset according to the univariate Cox’s analysis ID HR HR.95L HR.95H P value TGFB2 0.42708 0.191306 0.953432 0.037862 DPP4 0.23281 0.097197 0.557638 0.001074 CDK6 … ... as both an oncogene and tumor suppressor, a literature search was performed to determine the role of the specific gene in tumor development. S1 to S6 . endobj �g�;k:E?g�EHI�O�;�1k�r��A�ܫn�εd�o�� ����:&R*�$I��HoC1:���VsI\��DqNR-�V(Ji�i�q�:h3���A_�_����>��^g���aq� endstream 1167 0 obj <>/Filter/FlateDecode/ID[]/Index[1154 20]/Info 1153 0 R/Length 69/Prev 82264/Root 1155 0 R/Size 1174/Type/XRef/W[1 2 1]>>stream That is they both together produce a particular phenotypic trait in an individual. Supplementary genes are the genes which include two pairs of non-allelic genes. stream Typical Di-Hybrid Ratio (9:3:3:1): This type of gene interaction produces the typical di-hybrid ratio of … This PDF file includes: Materials and Methods . Such genes affect the development of … We then computed the following tests: (i) shortest distance between pairs of proteins in the interaction network whose genes are adjacent in the genome; (ii) number of Here one dominant gene has its own phenotypic effect and other dominant gene has no effect of its own but its presence with the first genemodified the phenotypic expression. The nucleotide sequences of the BRSV strains subjected to the phylogenetic analysis were used. Supplementary Table S6 (PDF, TXT format). &����w�&Ɛ%;�6�xޛ7k��;�P;�V� �5�Dk$���%^�7�� R:7������'���O�%�ɾV(��1�j����>F�O-��mHV|Q!x�Z�d��_HH&7��}��/��0�C6p��p�K�IH1y߇i���+I��bh���xǰ����[�T�E ���C� Zx���\$�~ p ���Y����$�7�at\.2dA����$��kA�R� r9����.�����lV,s���N\:�n����ʼ��y�R6�K�� Ei1��-�'3�s��1:��� (Recessive epistasis) 9:3:4 . Genes that are potentially targeted by miRNAs selectively accumulated in HL relative to tissues during young age. "�AD&�0 �ځX���s ��E�b``D'����` Q� Trans. Genes are sorted so as to highlight discrepancies between our data and gene essentiality data of Blattner and colleagues, and the PEC database. Ligand-receptor interactions in mDRG sensory neurons and each of the 42 cell types in mDRG-innervated tissues from Tabula Muris, along with GO annotations. Individual genes may very well have sharp expression territories from one cell to a neighboring cell. P a g e | 1 GENE INTERACTION UNIT II (B): GENE INTERACTIONS Mendel and other workers assumed that characters are governed by single genes but later it was discovered that many characters are governed by two or more genes. Sequence and unique phylogeny of G genes of bovine respiratory syncytial viruses circulating in Japan Supplementary Table 1. AKAP9 A kinase (PRKA) anchor protein (yotiao) 9 10142 7 7q21-q22 yes Papillary thyroid E Dom T BRAF KIAA0803; AKAP350; ... genes we compared the functional distribution of the triplet genes against the entire wheat Genes that are potentially targeted by miRNAs selectively accumulated in HL relative to tissues during young age. 25 marker genes associated with each k nearest neighbor (kNN) cluster. Gene interaction -Complementary, Supplementary,Dominant Epistasis, Recessive Epistasis, Non- Epistasis, 1. 2. Please contact the editorial office for further information. S1 to S25 . Ranges of pairwise similarities (%) of the G gene sequences among 10 subgenotypes. Figs. ... genes in a pairwise fashion to obtain a Pearson correlation coefficient for each gene as a measure 4 0 obj Supplementary table 1. The expression of the colour genes is masked if pp is present. Supplementary Material for . Identification and characterization of essential genes in the human genome . In this table essential E. coli genes are organized in the three main groups: Gene interaction Harshraj Subhash Shinde KKW, CABT, NASHIK 2. Gene interaction -Complementary, Supplementary,Dominant Epistasis, Recessive Epistasis, Non- Epistasis, 1. Ranges of pairwise similarities (%) of the G gene sequences among 10 subgenotypes. Supplementary Material for . (B) SPRING plot illustrating the 13 identified clusters. (XLS) Supplementary Table 3. Loci significantly changed compared to wildtype (genes: FDR 0.01 and log2 fold change >2 - or <-2; repetitive elements: FDR 0.05 and fold change >2 or <-2) are colored according 1173 0 obj <>stream Supplementary Figure S1 The number of common and unique mutations in different components. Such genes affect the development of concerned … Thus in supplementary gene action the dominant allele of one gene is necessary for the development of �X;ڙ9s���LV�pv���\]����� $�͝���p��dU�������5�5��|�R���ˇ���i�O�7U�B}��j㜺>>kS��x���h����N��ޫ �Yμ"?������qB��$|��M�@�?��5�1��ތ�S�90.���04�����dP�h�#|�A��mri���F��Nޮ�W��|��$�~�A�ȏ���9G��Eb�j�w�^+�� ��0�HH�Zr��v��D�_���*x��t|�0���;,,8*�NIF�\.�p�e�g./Ű%�t8/�����6d endobj << /ProcSet [ /PDF ] /XObject << /Fm1 5 0 R >> >> R. Soc. S1 to S18 Genetic footprinting procedure . Please contact the editorial office for further information. << /Length 8 0 R /Type /XObject /Subtype /Form /FormType 1 /BBox [0 0 792 612] Our assumption just states that overall, expression of individual genes should only rarely look like salt and pepper patterns but should be organized, for most genes, in (gene specific) spatial territories. 3 0 obj Supplementary Table S2 (PDF, TXT format). GWAS and OMIM yield lists of genes and associated diseases; however, gene and disease annotations and nomenclature are not standardized, and, furthermore, the levels of disease speci cation are very heterogeneous. �p=�A»� Supplementary Material for . Supplementary Table 3: A list of oncogenes and tumor suppressors used in the comparison of gene functional groups. Adjacent genes with d<3 P <0.0001 Generalized clustering coefficient P <0.0001 We eliminated one of the two genes from a tandem pair and re-assembled a new network. Results: additional illustrations and analysis . If the Sorghum is pp, it is brown inspite of other genotypes. /�")�Qδ9��[�f�,78`&v������.�j٣�r�:�Q�*?� ��)6�C�W����. Genes Common mutation SCLC [6], frequency SCC [6], frequency TP53 5 5 5 RB1 2 2 2 SOX2 1 4 3 CDKN2A 2 2 2 FGF19 1 1 2 FGF3 1 1 2 Supplementary Table 3 Values used for calculating fold change of free fatty acid receptor 2 and 3 genes using quantitative real time polymerase chain reaction Sample type Gene Ct Mean Adj. The genes for recessive epistasis are also called supplementary genes because the gene P determines the formation of colour. h�bbd``b`:$�A� endstream endobj 1158 0 obj <>stream Data file S2 (Microsoft Excel format). %%EOF xڵWMo�@�ϯ���!����ki�R�VA�QG� A full list of cancer genes. 5 0 obj genes downregulated in non-luminal-like tumors. Correlation between the fold change (log2) over wt for gene (top) and repetitive element (bottom) expression between -2, set-25 and lin-61 met single mutants. �T�����������Xg{9��Z����2��9�e���S2A���h2��. In this table essential E. coli genes are organized in the three main groups: << /Type /Page /Parent 7 0 R /Resources 3 0 R /Contents 2 0 R /MediaBox Figs. Supplement to: The Severe Covid-19 GWAS Group. b. Supplementary table 2. The distribution of the metabolism-related risk score (Top); patients’ overall survival status and time (Middle); heatmap of the expression profiles of the five genes in the signature (Bottom). %PDF-1.3 Gene interaction 1. Ct Mean ΔCt Mean ΔCt SE ΔΔCt RQ Tumor FFAR2 27.9012 27.9012 5.339917 0.741014 0.90544 0.53387 Thus in this example, the gene `p' is epistatic to the other colour genes. Identification and characterization of essential genes in the human genome . V. Experimental and Analytical Procedures: 1. Downloaded from rstb.royalsocietypublishing.org on April 22, 2014 Elevating crop disease resistance with cloned genes Jonathan D. G. Jones, Kamil Witek, Walter Verweij, Florian Jupe, David Cooke, Stephen Dorling, Laurence Tomlinson, Matthew Smoker, Sara Perkins and Simon Foster Phil. supplementary table s1: fetalis 758 genes # gene # gene # gene 541 pvrl1 586 rttn 631 smc1a 542 pycr1 587 runx2 632 smc3 543 rab18 588 ryr1 633 smoc1 544 rab23 589 sacs 634 sms 545 rab3gap1 590 sall1 635 snap29 546 rab3gap2 591 sall4 636 snip1 547 rab40al … 0 Supplementary Text . Supplementary Figure 2. %��������� endobj %PDF-1.5 %���� Thus, 30 genes were filtered out as candidate genes. 23 Supplementary gene action (9:3:4) b. Complementary gene action (9:7) c. Inhibitory gene … Of those DEGs, 23 genes from the PAM50 subtype signature were selected since they showed stable expression pattern across different cohorts. (PDF) Supplementary Table 3. 1. SUPPLEMENTARY MATERIAL FOR SENIOR SECONDARY BIOLOGY National Curriculum for 2012 (Class XI & XII) has been revised ... Each gene has a certain amount of effect, and the more the number of dominant genes, the greater expression of the character. h�b```�l�~�g`��0pL```4�b``���} �!�eF����S�F"��`�hP� � ����!C+�pQ���@���@�1�0�20��&x��y��B���/`� �F��Q ������J5���n R0 �2*� Chicken Z amplicon predicted genes and coordinates Supplementary Table 3. Besides, 7 genes reported to correlate with breast cancer were added based on current literatures. [Download PDF] Other Supplementary Material for this manuscript includes the following: Data file S1 (Microsoft Excel format). Supplementary Table 1. Supplementary Text . In mice, black coat color is monogenically dominant over albino and agouti. /Resources 6 0 R /Filter /FlateDecode >> JVDI Supplementary material Kumagai A, et al. Genes are sorted so as to highlight discrepancies between our data and gene essentiality data of Blattner and colleagues, and the PEC database. �q6'؟ ��1�>"a����?��wp~>��q��[��`Y�|8��Hk����E�|���i}S �������V'� 1�ӗa�\Z��y����E��`�A�� �]׉��� X��Sf'���&�U�sP�pB�ƜԿL���,Sg Vȓk� Supplementary Table 5 Mapping of TRANSFAC motif models to gene names Supplementary Table 6 Merging of DHSs from 79 cell types into 32 categories Supplementary Table 7 Promoter/distal DHS pairs with correlation ≥ 0.7 Supplementary Table 8 Gene sets … �`�� G� P a g e | 1 GENE INTERACTION UNIT II (B): GENE INTERACTIONS Mendel and other workers assumed that characters are governed by single genes but later it was discovered that many characters are governed by two or more genes. h��UK��0�+:����-Ɇe!I��� �����������B��W3���k�Mm��y~�?s���*%V͈�l8�Q�ag��EdN���Q��+�W&�����e^u�3��8�}ʋ��#�+�!�M�H+:)�uK"A'uՍF���@�m�2c�`��I�-��wæ�����϶9��`T��/3�N�&�z_7۬Dգ���벲X�u�F�]�}07Rt�����5Ů��͢�՚>հj�Mۍ7Yc << /Length 4 0 R /Filter /FlateDecode >> In the end, 105 genes were plotted for 3623 cells. Supplementary Genes: Supplementary genes are a pair of non-allelic genes, one of which produces its effect independently in the dominant state while the dominant allele of the second gene (supplemen­tary gene) needs the presence of other gene for its expression. H�|S�j�@}�W��.t�8R!�8nI!i �RJi�4R���}�k Supplementary gene action. endobj Outline • Introduction • Types of gene interaction • Epistatic and hypostatic gene • Classification of epistatic gene interaction a. Log2 normalized counts were gene scaled and plotted for all cells analyzed. Figs. {.���J�����:Z ?�X�{��(-�����aMN0�a���m��:�"B����oȢ�H���Ӵjo�U����7��!k:�7h5x�s����[Z=һ��Z�)� ;Cl� IV. This PDF file includes: Materials and Methods. 2 0 obj Supplementary Figure 3. (C) Top 25 upregulated genes in E-cadherin-expressing cells from cluster 13. III. Supplementary Materials for Systematic humanization of yeast genes reveals conserved functions and genetic modularity Aashiq H. Kachroo, Jon M. Laurent, Christopher M. 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