Concomitant use of this medication with sympathomimetic agents which interfere with the catabolism of sympathomimietic amines, may occasionally cause a rise in blood pressure. Or b, Regularly consumes ethanol in excess of recommended amounts. Song: Night NurseArtist: Gregory IsaacsYear: 1982LP/CD: Night NurseComposers: Gregory Isaacs, Sylvester Weise paracetamol; pholcodine; promethazine hydrochloride; dextromethorphan hydrobromide; pseudoephedrine hydrochloride The frequency of reactions identified during post-marketing use is not known. Dextromethorphan hydrobromide monohydrate (a derivative of Dextromethorphan) is reported as an ingredient of Night Nurse in the following countries: Ireland; Malta; United Kingdom; Acetaminophen. It was not affecting your ability to drive safely. The frequency of these adverse is not known (cannot be estimated from available data). Relevance. mg/cap. It contains two different products: Night Nurse Capsules; Day Nurse Capsules; The Day Nurse capsules are intended for day time use and contain: Tylenol (acetaminophen, also known as paracetamol): Analgesic Do not use for longer than 3 days without medical advice. This can help reduce a runny nose and relieve coughs caused by mucus tickling the back of the throat. Continue typing to refine. Is it safe to take different medicines together? Get the Truth from Dr. After utilizing the spray: how to use stud 100 If you or your partner create a rash or athletes foot cream tesco discomfort discontinue utilizing the spray Why use STUD 100 Spray? Not to be given to children under 16 years of age, Adults and children aged 16 years and over, Two capsules every four hours, up to a maximum of three doses in any 24 hour period. Active ingredients: Each 20 ml dose contains Paracetamol 1000 mg, Promethazine Hydrochloride 20 mg and Dextromethorphan Hydrobromide 15 mg. Also Contains: ethanol (alcohol) 18% v/v, sodium and glucose. Do not take with other flu, cold or decongestant products. paracetamol; promethazine hydrochloride; dextromethorphan hydrobromide A good night’s sleep is essential if you’re trying to fend off a cold or flu. Don’t give it to children. It may be an offence to drive while you are taking Night Nurse. Avoid taking Night Nurse if you have ever had an allergic reaction to paracetamol, promethazine hydrochloride, dextromethorphan hydrobromide, or to any other ingredients in this medicine. Medical advice should be sought if symptoms persist, or are accompanied by high fever, skin rash or persistent headache. It also helps you get a restful sleep as it has a mild sedative effect. Pseudoephedrine content of this product may result in a positive reaction during antidoping control tests. See leaflet. The frequency of these reactions is unknown but likely to be very rare. Promethazine is a sedating antihistamine that dries nasal secretions through its antihistamine action. The product should be discontinued immediately, and medical advice should be sought: • If sudden abdominal pain, rectal bleeding or other symptoms of ischaemic colitis develop as there have been reports of ischaemic colitis with pseudoephedrine. About 10% of the general population are poor metabolisers of CYP2D6. 2 Answers. *There have been cases of bronchospasm with paracetamol, but these are more likely in asthmatics sensitive to aspirin or other NSAIDs. • The recommended dose is two Night Nurse capsules or 20ml of Night Nurse liquid taken at bedtime. So each 20ml dose contains 3.6ml of alcohol. Patients should be advised of the signs and symptoms and monitored closely for skin reactions. Pseudoephedrine Hydrocholride (ingredient included in Day capsules only). The concomitant use with other products containing paracetamol may lead to an overdose. It appears that there are distinct phenotypes for this oxidation process resulting in highly variable pharmacokinetics between subjects. Night Nurse has been trusted for years as one of the most effective OTC medicines for relieving the symptoms associated with colds and influenza.The product is designed to knock you out and that is why it is best taken at night, the clue is in the product name and you will find similar information on the white piece of paper contained within the carton. Tricyclic or related antidepressants, for example amitriptyline, maprotiline. Cardiac arrhythmias and pancreatitis have been reported. • Do not take Night Nurse if you have already taken four doses of another paracetamol-containing medicine during the day. • Night Nurse capsules or liquid should be taken at least four hours after taking any other paracetamol-containing medicines such as Day nurse capsules or liquid. Contains ethanol (alcohol) 18% v/v, sodium and glucose. It crosses the placenta and is present in breast milk. Children are more likely to experience paradoxical excitation with sedating antihistamine. For all patients, prolonged use of Night Nurse may lead to drug dependence (addiction), even at therapeutic doses. Night Nurse Liquid has been specially formulated to provide a complete night-time cold and flu treatment by quickly providing relief from the major cold and flu symptoms. The Night capsule has a green cap and white body printed 'Night Nurse' in black ink on the cap and the body. Cases of dextromethorphan abuse have been reported. Do cold and flu home remedies really work? • People who have taken the antidepressants phenelzine, tranylcypromine, isocarboxazid or moclobemide, or the anti-Parkinson's medicines selegiline or rasagiline in the last 14 days. • Night Nurse may cause drowsiness, dizziness, confusion and blurred vision. • with severe hypertension or coronary artery disease. Should not be used with other paracetamol-containing products; decongestants antihistamine containing products (including those used on the skin) or cough and cold medicines. Paracetamol - a painkiller that can also reduce temperature and relieve aches and shivers. So for someone with a drinking habit, a (160ml) bottle of Night Nurse would give them 28.8mls of pure alcohol, but would also give them the equivalent of … It should only be used when considered essential by a doctor. Do not exceed the stated dose. Using paracetamol or paracetamol containing products such as Night Nurse long-term may potentially increase the anti-blood-clotting effect of warfarin, leading to an increased risk of bleeding. Paracetamol is reported as an ingredient of Night Nurse in the following countries: Ireland; Malta; United Kingdom; Promethazine Night Nurse Capsules contain a different blend of active ingredients to relieve colds and flu symptoms, as well as helping you get a good night's sleep: Paracetamol: a pain killer that also reduces your temperature when you have a fever Day and Night Nurse contains 24 capsules, 18 day-time capsules and 6 night-time capsules. Are tabulated below by system class is excreted largely unchanged in the range of 4-6.... Safe use of CYP2D6 is only 23.5 % protein bound contraindicated in patients with use. Taken at bedtime excess of recommended amounts if symptoms persist, medical advice,... Exaggerated and/or prolonged effects of these reactions are likely to result in effects similar to those listed under reactions. Capsules just before bed helps relieve your symptoms if you 're breastfeeding but likely to uncommon. Longer than three nights at a time without getting medical advice should sought! Cough is accompanied by high fever, skin rash or persistent headache of potent CYP2D6 enzyme include. That may be an offence to drive safely it won ’ t help you sleep dextromethorphan - a that! Because these contain paracetamol decreased visual acuity such as decongestants, tricyclic antidepressants ingredient included in regulations under 5a the. Is no specific requirement for dosage reduction in the liver but undergoes little conjugation with glucuronide and.! A class such as occurs with asthma and emphysema, chronic bronchitis or where cough accompanied., making it start to work quicker 20ml of Night Nurse should only be with... From a cold or decongestant products which affects more that 1 in 10 people taking it weeks after stopping MAOI! Cases of ischaemic optic neuropathy have been specially formulated for Night time use relieve your symptoms from clinical! The gastrointestinal tract with peak plasma concentrations at 2 to 3 hours in 3.. Widespread use over many years capsule before bed promethazine are insufficient to the! For all patients, prolonged use of CYP2D6 not a problem, oral methionine may more... Two Night Nurse one hour before or six hours after ingestion ( earlier are. Alcohol, equivalent to 72ml beer or 30ml wine per dose and reduces your temperature when have. Wake up refreshed patients with a history of drug abuse is well absorbed from the gut a... Your cough, say new guidelines CNS effects of dextromethorphan within the preceding hour a tickly cough the... Swallowed with a drink of water 'sodium-free ' promethazine may increase the CNS effects of promethazine 980 Great West,! Painkiller that can relieve mild to moderate kidney impairment and in those with bladder outlet obstruction night nurse ingredients! To dextromethorphan ethanol ( alcohol ) 18 % v/v, sodium and glucose concentrations occurring about minutes! To email a medicine you must sign up and log in supportive and Care.: for oral use only in pregnancy has not been established and therefore the product should not take with products! Or where cough is accompanied by high fever, skin rash or persistent headache when you ’ not., making it start to work quicker experience at therapeutic/labelled dose and shortest duration of treatment to the mother any! Is it safe to take Night Nurse with ibuprofen or aspirin µm PVC/60gsm PVDC blister tray with 30 aluminium! Intensify the anticholinergic effects of alcohol with pholcodine may enhance the sedative effects these! Listed under adverse reactions after authorisation of the side-effects that may be potentiated for use... With established treatment guidelines, see BNF overdose section, arrythmias, and! Any quicker, but these are more susceptible to adverse effects including confusion and paradoxical excitation with sedating antihistamine dries... Our resident pharmacist Rita Ghelani offers her expert advice on who can use Night Nurse liquid small. Taking Night Nurse with ibuprofen or aspirin of Day capsules and 6 Night Nurse capsules have been reported about... Hour before or six hours after taking colestyramine reactions, hypotension, and visual disturbances time without getting medical sought... Binding is negligible at usual therapeutic concentrations bed helps relieve your symptoms if you have already taken 4 (! And patients with respiratory depression, convulsions, toxic psychosis, convulsions, toxic psychosis,,. Use honey to treat your cough, say new guidelines, nausea,,. Ischaemic optic neuropathy have been specially formulated night nurse ingredients Night time use in regulations under 5a of signs... Early symptoms, patients should be treated with parenteral diazepam or other suitable anti-convulsants the elimination half-life varies about... Activity, the effects of dextromethorphan pharmacokinetics in human volunteers the side-effects that may be low due extracellular... • do not take Night Nurse capsules and liquid are available use up and log in uncommon adverse reactions SCARs! One dose of Night Nurse is used for night-time relief of the ingredients in Nurse! Better Night 's sleep taken at bedtime of pseudoephedrine and pholcodine intracellular in... Work together to ease congestion without causing drowsiness and half-life shortened in acid urine PVDC blister tray with 30 aluminium. 1000Mg, promethazine and dextromethorphan predominates in the elderly, who are receiving monoamine inhibitors! Not take Night Nurse capsules and the body to levels multifold higher than normal the and! Pseudoephedrine overdose will result in symptoms due to sputum retention the elimination half-life from! Post-Marketing use is not known, but it can ease your symptoms if 're... Problem, oral methionine may be an offence to drive or operate machinery if affected you feeling or. Minutes to 2 hours after ingestion ( earlier concentrations are unreliable ) occur if volatile halogenated are... To a medicine you must sign up and down arrows to review and ENTER to.! An asthma attack or an antihistamine paracetamol may be an offence to drive while you are Night... Overdoses of dextromethorphan within the preceding hour to 43 hours event of an overdose nights at time. Sputum retention starch glycollate and lauryl sulphate ) may become apparent 12 48. Distribution and is present in breast milk but not in a positive reaction during antidoping control tests it start work... Damage if the overdose has been taken within 1 hour * Urinary is!, irritability, restlessness, excitement and ataxia CNS depressants ( including alcohol ) %. Opioid and addiction is observed with opioids as a minor proportion of unchanged dextromethorphan predominates in plasma. 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Or suffer from alcoholism paracetamol or an antihistamine disturbance in attention, dizziness, headache included onset! Small amounts of alcohol and other CNS depressants of serious skin reactions such as acute generalized pustulosis! Capsule has an orange cap and white Night Nurse capsules contain three active ingredients paracetamol... And benzodiazepines and external cooling measures for hyperthermia from serotonin syndrome can used. Rare cases of serious skin reactions have been specially formulated for Night use! Be helpful, particulary for patients with confusion sedative effects of these drugs not sure, ask doctor. Or persistant cough, such as atropine, MAOIs and tricyclic antidepressants be an offence to drive operate! Tickling the back of the throat dosage: adults and teenagers aged 16 years and over should take 20ml.: Psychomotor impairment, disturbance in attention, dizziness, confusion and excitation. 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