While the discovery of yet another worrisome variant is concerning, it's not the variant that California in particular should be focused on, according to Chin-Hong. But he added: "Will it be worse if they're together?" Those two are the variant found in the UK, which is linked to 851 cases in California, and another variant first spotted in Southern California. This "double mutant" strain has been named B.1.617. However, in the India's case, double mutant variant has been detected in fewer samples than the UK variant, which is … Account active ICMR-NIV recently has been successful in isolating and culturing the double mutant strain B.1.617 SARS-CoV-2 identified in certain regions of India and several other countries, the ICMR stated. Earlier, if one sick person was able to infect around 30 per cent of their contacts, this time those getting the disease are infecting a larger number of people, he said. The double mutant was reported in 15-20 per cent of cases analysed from Maharashtra, the state which accounts for lion's share of coronavirus cases in the country. 📣 The Week is now on Telegram. What is the double mutant virus, and what are its dangers? People not adhering to COVID-appropriate behaviour and the circulation of highly infectious strains of SARS-COV-2 could be the primary reasons behind the surge in coronavirus infections in India, AIIMS Director Dr Randeep Guleria said. The Indian government says there's not enough evidence to link that surge to this variant, but epidemiology researchers at the Indian Institute of Public Health have suggested that it's the most likely explanation. The two mutations make it more difficult for the immune system to recognise the coronavirus.Â, Both the E484Q mutation (reported in both UK and South African variants) and L452R mutation (found in the California strain) have been associated with much greater binding and antibody escape capabilities.Â, However, the effect of the double mutation should not be overstated. This is something we flagged two months ago. Also, it has to be ensured that there is no gathering and stricter enforcement of COVID-appropriate behaviour has to be ensured". Mumbai Police personnel are tested for the coronavirus on October 15, 2020. New 'Double Mutant' Coronavirus Variant Found In California Eric He 12 mins ago. The California Department of Public Health reported last week that the latter accounts for more than 6,200 of the state's cases. But Dr. Peter Chin-Hong, an infectious-disease expert at the University of California, San Francisco, said panic about the variant is premature — and its nickname is a bit sensational. Various strains of SARS-CoV-2, including the UK, South Africa and Brazil variants, are circulating in India and have been termed as highly transmissible by experts. Get the latest healthcare news and analysis. This variant is fast spreading, has exponential growth and has strained our health system. Get it now on Libro.fm using the button below. "We may lose the gains we have made so far if we do not pay heed now," and the situation may completely get out of control, he said. Sore throat: If you have a prickly, itchy throat or if you feel some swelling, it can be indicators of a sore throat, which is one of the most common symptoms of COVID-19 infection. If you go out, you see that marketplaces, restaurants and shopping malls are crowded and full of people and these all are super-spreader events," Guleria said. No studies yet have found that this "double mutant" is deadlier than earlier versions of the virus, or that it can evade vaccines. By clicking ‘Sign up’, you agree to receive marketing emails from Insider The double mutant strain of Coronavirus has been named B.1.617. The double mutation B.1.617, according to multiple reports, trigger changes in the spike protein that make it more infectious to humans. One mutation, known as L452R, helps the virus' spike protein bind more tightly to cells. The other mutation — called E484Q — bares a "chilling" resemblance to a mutation found in variants from South Africa and Brazil, according to Chin-Hong. "However, with newer strains in play, we are likely to see newer symptoms. Researchers from the Clinical Virology Lab at Stanford identified this "double mutant" in a sample from a patients in the San Francisco Bay Area. They suspect another seven cases are linked to the variant. Biden moves up deadline to make all adults eligible for vaccine by April 19. 2021-04-06T21:11:07Z The letter F. An envelope. A new COVID-19 variant named "double mutant" was found in the Bay Area recently and experts are concerned it may spread faster than others. India is seeing a significant surge of CoViD-19 starting 2021 caused by a "double mutant". Experts worry India's second wave of COVID-19, said to be much more dangerous than the first wave last September, is to be blamed on a new and possibly more virulent "double mutant… Just 24 hours after Indian officials reported the variant, it also popped up in northern California. It was the National Centre for Disease Control (NCDC) who first announced that a new variant had been identified in samples of saliva taken from people in Maharashtra, Delhi and Punjab. Why this new variant may be worrisome . The variant has earned the somewhat ominous nickname "double mutant" because it has an unprecedented combination of two mutations that may help it both attach better to human cells and hide from the immune system. So far, all vaccines in circulation have been reported to be effective against all kinds of virus variants, and the ongoing surges have not been empirically linked to the B.1.617 mutation.Â, Centre rings the alarm bell on COVID surge. A new coronavirus variant has been detected in India and northern California. Simply put, the double mutant in India, identified as B.1.617, carried two mutations—E484Q and L452R—in the crucial spike protein part of the pathogen. Chin-Hong also thinks the "double mutant" will have a harder time spreading in California because the state's winter surge of cases, coupled with rising vaccinations, have left fewer residents vulnerable to infection. Every variant has a unique genetic code peppered with mutations — that's how researchers can classify different strains. We don't really know how they're going to interact.". Another worrisome coronavirus variant has made its global debut. At that point of time, there was no clear indication of its role in the Maharashtra surge. Coronavirus: ‘Double mutant' variant found in California's Bay Area It's unclear if the variant can cause reinfections or is more resistant to vaccines The publication quoted Dr Shashank Joshi, member of the state Covid task force as saying: “Entire families are getting infected. Jerry Pinto's new poetry collection is warm and wise. In the last week, Maharashtra saw a 55% increase in infections. Plus, he added, many variants have multiple mutations. Scientists from the Indian state of Maharashtra identified a new strain two weeks ago that's linked to between 15% and 20% of cases there. This increases its transmissibility and ability to bypass the immune response.Â, The double mutant was reported in 15-20 per cent of cases analysed from Maharashtra, the state which accounts for lion's share of coronavirus cases in the country. How dangerous is India’s ‘double mutant’ COVID-19 variant? since, “No Rules Rules: Netflix and the Culture of Reinvention”. "There's a reasonable amount of information about those individually," Pinsky said of the two mutations. "So, the rate of spread of the infection is fast possibly due to the highly infectious and transmissible strains circulating," he added. Anshuman Poyrekar/Hindustan Times via Getty Images. The S-protein on the surface of the virus (the same ones that give the virus its signature crown shape) bind to the ACE2 receptor. That said, some "early hallmarks" suggest the variant could be more transmissible, Chin-Hong said. Around 60 per cent of the cases in Maharashtra have the double mutant strain, although capital Mumbai hasn't reported this. Ten years of Anna Andolan: Who benefited from the anti-corruption movement? "We don't know how those two mutations behave when they're paired together," Dr. Benjamin Pinsky, a Stanford virologist who helped discover the variant, told the LA Times. Subscriber And we need district-wise sequencing to understand local viral behaviour.”. When SARS-CoV-2, the novel coronavirus, enters your body, it binds itself to tissues with high concentration of angiotensin-converting enzyme II (ACE2), high levels of which are present in the lungs. ACE2 is a receptor on the surface of the cells, connecting the outside through the cell membrane to the insides of the cell. In the last week of March, when cases began to rise in the country, the Union health ministry had said that a new "double mutant" variant of SARS-CoV-2 was detected in Delhi, Maharashtra and some other places. "It suggests that it is doubly scary or doubly transmissible even compared to a variant that we know about, but there is no evidence to suggest that," Chin-Hong told Insider. Guleria said the entire humanity is going through a difficult time and "unless it is important, people should not venture out. He also warned that if the situation is not reversed, then the galloping infection rate will eventually cause a huge strain on the country's healthcare system. The Stanford Clinical Virology Lab discovered there’s at least one case of the double mutant COVID-19 variant — originally discovered in India — found in California. A leading-edge research firm focused on digital transformation. But there's no evidence yet that the variant is "doubly scary" or "doubly transmissible," an expert said. The genome sequencing carried out by Indian SARS-CoV-2 Consortium on Genomics (INSACOG), a consortium of 10 labs in India, identified two important mutations in the variant dubbed as "double mutant". ‘Double mutant’ coronavirus variant found in California. At that point of time, there was no clear indication of its role in the Maharashtra surge. Dr Khan examines what we know so far about the new variant. That same mutation is also present in a variant first spotted in Los Angeles last fall. The so-called 'double mutant' COVID-19 variant combines mutations that have been observed in other coronavirus variant, but never together. This was in addition to the three "variants of concern"—emerging out of UK, South Africa and Brazil—that were reported in at least 18 states and Union territories. A double mutant variant of a virus is not a rare occurrence even if not very common. "This all acts as a force field — albeit temporary — against these new variants," he said. Click here to join our channel (@TheWeekmagazine) and stay updated with the latest headlines, here to join our channel (@TheWeekmagazine), Biden calls for peace after unrest following police killing of Black man in Minnesota, IPL 2021: Mumbai Indians beat Kolkata Knight Riders by 10 runs, Akshaye Khanna, Raveena Tandon team up for web series 'Legacy', Govt not going for lockdowns in big way, says Sitharaman to World Bank, UAE names its first female astronaut, set to train with NASA. 18 to 19 states, or 70 to … So far, the double mutant has been reported from countries across the world. The "double mutant" brings together two worrisome mutations in the same variant for the first time. The majority of patients have: a fever, pain in muscles, dry and persistent cough, and; loss of smell and taste. A 'double mutant' coronavirus variant found in India was spotted in California — but there's no evidence it's 'doubly scary' Aylin Woodward. The Stanford lab identified one confirmed case of … A … But some may or may not experience these and have additional symptoms like: conjunctivitis, sore throat, headache, rashes, upset stomach, and Now, The Indian Express has reported NIV data showing that, of 361 COVID-19 samples taken in Maharashtra from January to March, 61 per cent had the double mutation. "I do not at this time think that this 'Indian variant' will dominate the California viral landscape," he said, adding, "we already have two svelte and dastardly variants adept at transmission duking it out.". "Around February, when cases started to decrease, people became lax towards following COVID-appropriate behaviour as they thought the virus had become ineffective. E484Q is a key mutation in this strain that enhances ACE2 receptor binding ability and reduces existing antibodies from attaching to this mutated, hence differently folded, spike protein. It has a combination of mutations that may help it spread more quickly or evade vaccines. Amid the rising cases of coronavirus in the country, the Health Ministry on Wednesday said that a new ' The double mutant of the coronavirus which can't be detected by the COVID test has series of strange symptoms which are listed below: 1. That tweak helps the variant evade detection by antibodies the body has developed in response to an infection with the original virus. The “double mutant” coronavirus variant has been discovered in California, Fox News reports.. Where was the double mutant found? "People are taking the disease lightly now. Alameda County workers line up to receive coronavirus vaccines outside St. Rose Hospital in Hayward, California on January 8, 2021. The health ministry on Wednesday said a "double mutant" variant of coronavirus has been detected in over 10,000 samples analysed across 10 national labs. as well as other partner offers and accept our, Allen J. Schaben / Los Angeles Times via Getty Images, Jessica Christian/The San Francisco Chronicle/Getty Images, NOW WATCH: How viruses like the coronavirus mutate, See more stories on Insider's business page, Anshuman Poyrekar/Hindustan Times via Getty Images, The California Department of Public Health reported. He sought stricter enforcement of COVID-appropriate behaviour on the ground level by the administration and authorities. India Today TV Consulting Editor Rajdeep Sardesai speaks to top doctors over the new double mutant variant of coronavirus that’s been detected in India amid a record surge of Covid-19 cases. "If the situation is not reversed, then the galloping infection rate will eventually cause a huge strain on the healthcare system also," he stressed. 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